Sarcoidosis and Pain Caused by Small-Fiber Neuropathy

Topical Phenytoin Cream Reduces Burning Pain Due to Small Fiber Neuropathy in Sarcoidosis Case Report

Introduction Burning pain as a symptom of small fiber neuropathy (SFN) is increasingly recognized as a medical problem, especially in the elderly and those patients suffering from diabetes. Symptoms of SFN typically start with burning feet and numb toes, and diabetes is in general regarded as the most common identifiable cause of SFN [1]. SFN and burning pain, however, can occur in many differe...

Quantification of small fiber pathology in patients with sarcoidosis and chronic pain using cornea confocal microscopy and skin biopsies

Small fiber pathology with concomitant chronic neuropathic pain is a common complication of sarcoidosis. The gold standard of diagnosis of small fiber neuropathy (SFN) is the quantification of small nerve fibers in skin biopsies in combination with patient history and psychophysical tests; a new technique is the quantification of small nerve fibers in the cornea using cornea confocal microscopy...

Small fibre neuropathy in sarcoidosis.

Some patients with sarcoidosis have unexplained pain and dysaesthesia. We did quantitative sensory testing in 31 sarcoidosis patients with pain or autonomic dysfunction. 25 patients had reduced warmth sensitivity, cold sensitivity, or both. Intraepidermal nerve fibre density (IENFD) was measured in punch biopsy skin samples in seven consecutive patients. All seven patients had reduced IENFD com...

Chapter 7 Small fiber neuropathy in sarcoidosis

Abnormal warm and cold sensation thresholds suggestive of small-fibre neuropathy in sarcoidosis.

OBJECTIVE A substantial number of sarcoidosis patients report apparently non-specific symptoms such as pain, for which no organic substrate has yet been found. Recently we observed symptoms suggestive of small-fibre neuropathy in a group of sarcoidosis patients. The aim of the present study was to verify this observation using various electrophysiological tests. METHODS In 74 sarcoidosis pati...